Chemical Properties
White or light yellow crystalline powder, slight specific smell, melting point 140-142 ℃. Soluble in acetone, chloroform, benzene, ethyl acetate, diethyl ether and methanol, almost insoluble in water. Rats by oral LD5070-100mg/kg, mice orally LD5050mg/kg, chicken LD50150mg/kg.
Uses
Salinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously.
The above information is edited by the chemicalbook of Tian Ye.
production method
It is produced by fermentation of white Streptomyces (Streptomyces albus).
Description
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1Salinomycin Na displays selective toxicity for cancer stem cells.1Induces rapid mitochondrial hyperpolarization.2Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4Kills cancer stem cells by sequestering iron.5
Chemical Properties
Brown Solid
Uses
Salinomycin is an ionophore
agent.
Uses
Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.
References
[1] PIYUSH B GUPTA. Identification of selective inhibitors of cancer stem cells by high-throughput screening.[J]. Cell, 2009, 138 4: 645-659. DOI:
10.1016/j.cell.2009.06.034[2] A MANAGÒ. Early effects of the antineoplastic agent salinomycin on mitochondrial function[J]. Cell Death & Disease, 2015, 6 10: e1930-e1930. DOI:
10.1038/cddis.2015.263[3] YINGZI FU. Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway.[J]. Oncology reports, 2016, 174 1: 912-922. DOI:
10.3892/or.2015.4434[4] KWANG-YOUN KIM. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.[J]. Molecular medicine reports, 2015: 1898-1904. DOI:
10.3892/mmr.2015.3633[5] TRANG THI MAI. Salinomycin kills cancer stem cells by sequestering iron in lysosomes[J]. Nature chemistry, 2017, 9 10: 1025-1033. DOI:
10.1038/nchem.2778
