ChemicalBook CAS DataBase List 55721-31-8

55721-31-8

Name	Salinomycin
CAS	55721-31-8
EINECS(EC#)	258-290-1
Molecular Formula	C42H71NaO12
MDL Number	MFCD00167109
Molecular Weight	791
MOL File	55721-31-8.mol

Chemical Properties

Melting point	140-142°
alpha	D25 -37° (c = 1 in ethanol)
storage temp.	APPROX 4°C
solubility	Soluble in DMSO.
form	neat
color	White
Merck	13,8415
BRN	4901827
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P405-P501
Hazard Codes	T
Risk Statements	25 less more
Safety Statements	45 less more
RIDADR	2811
WGK Germany	3
HazardClass	6.1
PackingGroup	III

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Brown Solid

Usage

Salinomycin is an ionophore agent.

Usage

Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.

Description

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5

References

1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645 2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930 3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912 4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898 5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025

Questions And Answer

Spectrum Detail

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55721-31-8

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