Chemical Properties
White Solid
Uses
A selective 5-HT4 receptor agonist. Gastroprokinetic.
Definition
ChEBI: Mosapride citrate dihydrate is a hydrate.
Biochem/physiol Actions
Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility.
in vivo
Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2].
| Animal Model: | Beagle dogs[2] |
| Dosage: | 0.3-3 mg/kg |
| Administration: | Intravenous injection; 0.3-3 mg/kg |
| Result: | Increased the antral motor activity dose-dependently in conscious dogs. |
IC 50
5-HT
4 Receptor; Kv4.3: 15.2 μM (IC
50)
