Uses
8(R),9(S)-EET is an isomer of Epoxyeicosatrienoic acid (HY-113489). 8(R),9(S)-EET processes its metabolism with cytosolic epoxide hydrolase (cEH), with a binding affinity of Km of 41 μM[1].
References
[1] Zeldin DC, et al., Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys. 1995 Jan 10;316(1):443-51. DOI:
10.1006/abbi.1995.1059[2] JORGE H. CAPDEVILA. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.[J]. The Journal of Biological Chemistry, 1990, 24 1: 10865-10871. DOI:
10.1016/s0021-9258(19)38526-6[3] YONGDE ZHANG. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.[J]. American journal of physiology. Heart and circulatory physiology, 2001, 280 6 1: H2430-40. DOI:
10.1152/ajpheart.2001.280.6.h2430
