Description
Thielavin A is a fungal metabolite originally isolated from
T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H
2 (PGH
2; ) and the conversion of PGH
2 to PGE
2 (; IC
50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC
50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from
S. cerevisiae (IC
50 = 23.8 μM; K
i = 27.8 μM).
Uses
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
