Originator
Butanixin,ZYF Pharm Chemical
Manufacturing Process
5 g 2-chloronicotinic acid and 9.4 g p-n-butyl aniline were heated for 1 hour
at 160°C by vigorous stirring under a nitrogen atmosphere. Then the mixture
was dissolved in 2 N sodium hydroxide and extracted with benzene. The water
layer was acidified and a precipitate obtained was filtered off, washed with
water and dried. 5 g 2-[(4-butylphenyl)amino]-3-pyridinecarboxylic acid
yielded. MP: 171°-173°C (deg.).
Therapeutic Function
Analgesic, Antiinflammatory
