Uses
Morphazinamide is an anti-tuberculosis agent. Also, it is derived from Pyrazinamide (P840600), which is an anti-bacterial (tuberculostatic).
Manufacturing Process
98.5 parts by weight 2-pyrazinecarboxamide was mixed with 260 parts by
volume of diethylamine. 91 parts by weight of 37% formaldehyde was added
to above mixture by stirring for 30 minutes. The reaction mixture was
spontaneously heated to 50°C. Then it heated to reflux for 5 hours on water
bath. After that it was distilled to dryness at temperature between 40°-50°C.
The residue was dissolved with about 200 parts by volume of ligroin (B.P.
60°C) by heating. The solution was filtered hot for removing the not reacted
2-pyrazinecarboxamide. Then it was cooled to -10°C and desired N-
(diethylaminomethyl)-pyrazinecarboxylic acid amide discharged. It was filtered
off and recrystallized from light petrol ester. Yield about 90%, MP: 47°-50°C.
500 parts by weight of N-(diethylaminomethyl)pyrazinecarboxylic acid amide
and 2500 parts by volume of was mixed and heated by stirring to temperature
140°-150°C. At 60°-100°C a distillation begun and ended at 127°C (a boiling
point of morpholine). The distillate consisted from diethylamine and
morpholine. After 30-60 minutes the mixture was cooled to 50°C and distilled
in vacuum to dryness. The residue was recrystallized from 400 parts by
volume of benzene to give N-(morpholinomethyl)pyrazinecarboxamide, yield
92%, MP: 114°-117°C.
