Preparation
4,5-dihydro-3,4,4-trimethyloxazolium iodide is prepared by alkylation of commercially available 4,4-dimethyl-2-oxazoline with Iodomethane (eq 1). Filtration and
purification affords the 2-oxazolinium salt in 80% yield.
[1]
General Description
4,5-dihydro-3,4,4-trimethyloxazolium iodide is a formylation and deuteroformylation reagent for aryl, benzyl, vinyl, and alkynyl Grignard reagents.
[1-2]
storage
4,5-dihydro-3,4,4-trimethyloxazolium iodide is slightly hygroscopic; stored under an inert atmosphere; use in a fume hood.
References
1. Meyers, A. I.; Collington, E. W. JACS 1970, 92, 6676.
2. Brinkmeyer, R. S.; Collington, E. W.; Meyers, A. I. OSC 1988, 6, 64.
