Description
PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity.
Chemical Properties
blue crystals
Uses
2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.
Uses
PTIO is a nitric oxide (NO) radical scavenger used to inhibit physiological effects of NO.
Synthesis Reference(s)
Journal of the American Chemical Society, 90, p. 1078, 1968
DOI: 10.1021/ja01006a053
General Description
Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.
Biochem/physiol Actions
Product does not compete with ATP.
