Description
15-
OxoEDE is produced by the oxidation of 15-
HEDE. 15-
OxoEDE inhibits 5-
LO from RBL-
1 cells with an IC
50 of 55 μM, which is about 2-
fold lower than 15(S)-
HEDE. A related oxo-
eicosanoid, 5-
oxoETE, is biosynthesized from 5(S)-
HETE by a specific dehydrogenase and has potent inflammatory activity.
Uses
15-OxoEDE is an ester product.
Definition
ChEBI: 15-oxoEDE is an oxoeicosadienoic acid that consists of 11Z,13E-oxoeicosadienoic acid with the oxo substituent located at position 15. It has a role as a metabolite. It is an OxoEDE and an enone. It is functionally related to a 15-HEDE. It is a conjugate acid of a 15-oxo-EDE(1-).
References
[1] F. HAVIV. ChemInform Abstract: Structural Requirements for the Inhibition of 5-Lipoxygenase by 15-Hydroxyeicosa-5,8,11,13-tetraenoic Acid Analogues.[J]. ChemInform, 1987, 18 28. DOI:
10.1002/chin.198728356
