Uses
P-TOLUENESULFONYLMETHYL CHLORIDE is used for synthesis of α,β-epoxy sulfones and alkylated sulfones; reacts with electrophilic arenes and heterocyclic arenes; source of α-p-tolylsulfonyl radicals.
Synthesis Reference(s)
1. Cinquini, M.; Colonna, S. JCS(P1) 1972, 1883.
2. Vogt, P. F.; Tavares, D. F. CJC 1969, 47, 2875.
Synthesis
P-TOLUENESULFONYLMETHYL CHLORIDE is synthesized by oxidation of the corresponding sulfoxide
1or by reaction of sodium ptoluenesulfinate with bromochloromethane.
2
Precautions
P-TOLUENESULFONYLMETHYL CHLORIDE should be used in a fume hood.
