![C-021 dihydrochloride Structure](https://www.chemicalbook.com/CAS/20210111/GIF/1784252-84-1.gif)
C-021 dihydrochloride
- Product NameC-021 dihydrochloride
- CAS1784252-84-1
- CBNumberCB55867403
- MFC27H42ClN5O2
- MW504.12
- MOL File1784252-84-1.mol
Chemical Properties
solubility | DMSO: 25 mg/ml; Ethanol: 5 mg/ml |
form | A crystalline solid |
color | White to off-white |
C-021 dihydrochloride Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Cayman Chemical 21885 | 1 mg | $59 | CCR4 Antagonist (hydrochloride) ≥98% |
Buy |
Cayman Chemical 21885 | 5 mg | $184 | CCR4 Antagonist (hydrochloride) ≥98% |
Buy |
ChemScene CS-0087635 | 5mg | $525 | C-021(dihydrochloride) >99.0% |
Buy |
ChemScene CS-0087635 | 10mg | $895 | C-021(dihydrochloride) >99.0% |
Buy |
ChemScene CS-0087635 | 1mg | $175 | C-021(dihydrochloride) >99.0% |
Buy |
C-021 dihydrochloride Chemical Properties,Usage,Production
Description
Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4.1 It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day.2 It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin when administered intrathecally at doses ranging from 10 to 30 μg/animal.3storage
Desiccate at RTReferences
1. Yokoyama, K., Ishikawa, N., Igarashi, S., et al. Discovery of potent CCR4 antagonists: Synthesis and structure-2. McMillin, M., Frampton, G., Thompson, M., et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline J. Neuroinflammation 11,121(2014).
3. Bogacka, J., Ciapa?a, K., Pawlik, K., et al. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia -
Preparation Products And Raw materials
C-021 dihydrochloride Suppliers
Global(14)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
+1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 | |
86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 | |
+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 | |
16314854226 | info@bocsci.com | United States | 9926 | 65 | |
15076683720 | klq@cw-bio.com | China | 3730 | 55 | |
400-1647117 15221909166 |
product02@bidepharm.com | China | 63720 | 58 | |
4008200310 | marketing@tsbiochem.com | China | 23963 | 58 | |
0371-55013243 15324716602 |
2853979810@qq.com | China | 10010 | 58 | |
021-65675885 18964387627 |
customer_service@efebio.com | China | 8739 | 58 | |
025-66113011 18112977050 |
cb5@aikonchem.com | China | 10529 | 58 |
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