Uses
1-Palmitoyl-sn-glycerol is an intermediate in the synthesis of lysophosphatidylcholines and related derivatives as immunomodulators.
Definition
ChEBI: 1-hexadecanoyl-sn-glycerol is a 1-acyl-sn-glycerol that has hexadecanoyl (palmitoyl) as the 1-acyl group. It is a 1-acyl-sn-glycerol, a 1-monopalmitoylglycerol and a monoacylglycerol 16:0. It is an enantiomer of a 3-palmitoyl-sn-glycerol.
Purification Methods
The stable -form is obtained by crystallisation from EtOH or Skellysolve B, and recrystallisation from Et2O provides the '-form. The -form is obtained on cooling the melt. [Malkin & el Sharbagy J Chem Soc 1631 1936, Chapman J Chem Soc 58 1956, Luton & Jackson J Am Chem Soc 70 2446 1948, Beilstein 2 III 966.]
References
[1] TRONG NGHIA NGO . Markhasphingolipid A, new phytosphingolipid from the leaves of Markhamia stipulata var. canaense V.S. Dang[J]. Natural Product Research, 2019, 34 13: Pages 1820-1826. DOI:
10.1080/14786419.2018.1561686[2] MAURIZIA MELLO-GRAND. Two Novel Ceramide-Like Molecules and miR-5100 Levels as Biomarkers Improve Prediction of Prostate Cancer in Gray-Zone PSA.[J]. Frontiers in Oncology, 2021: 769158. DOI:
10.3389/fonc.2021.769158
