Uses
1-Isopropylpiperidin-4-amine is used as a pharmaceutical intermediate compound for the preparation of antiviral compounds or small molecule bioactive inhibitors.
Synthesis
GENERAL METHOD: Compound I-5 (240 mg) was dissolved in hexafluoroisopropanol (HFIP, 8 mL) and 10% palladium/carbon (Pd/C, 120 mg) was added. The reaction mixture was stirred at room temperature for 20 h under hydrogen atmosphere (1 atm). Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give the yellow oily product I-6 (100 mg, 75% yield).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[2] Patent: EP1489078, 2004, A1. Location in patent: Page 130
![Carbamic acid, [1-(1-methylethyl)-4-piperidinyl]-, phenylmethyl ester (9CI)](/CAS/20200515/GIF/609804-23-1.gif)
