Biological Activity
UAMC-3203 is a ferroptosis inhibitor with IC50 of 10 nM in IMR-32 neuroblastoma cells.
in vitro
UAMC-3203 was incubated with human microsomes or rat microsomes, and the T 1/2 were 20.5 h and 16.5 h, respectively. When co-incubated with mouse microsomes, UAMC-3203 showed relatively poor stability, with a T 1/2 of 3.46 h.
in vivo
In mice, UAMC-3203 can significantly reduce the plasma concentration of lactate dehydrogenase. After administration, it is rapidly removed from the blood and enters various tissues. Significant levels of UAMC-3203 were detected in the tissues tested, such as liver, kidney and lung.
target
| Target | Value |
Ferroptosis
(IMR-32 neuroblastoma cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 10 nM
