UAMC-3203

Product NameUAMC-3203
CAS2271358-64-4
MFC25H37N5O2S
MW471.66
EINECS
MOL File2271358-64-4.mol

Chemical Properties

Boiling point	668.3±65.0 °C(Predicted)
Density	1.214±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Ethanol: Soluble
form	A crystalline solid
pka	12.27±0.50(Predicted)
color	White to off-white

Usage And Synthesis

Uses

UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.

Biological Activity

UAMC-3203 is a ferroptosis inhibitor with IC50 of 10 nM in IMR-32 neuroblastoma cells.

in vitro

UAMC-3203 was incubated with human microsomes or rat microsomes, and the T _1/2 were 20.5 h and 16.5 h, respectively. When co-incubated with mouse microsomes, UAMC-3203 showed relatively poor stability, with a T _1/2 of 3.46 h.

in vivo

In mice, UAMC-3203 can significantly reduce the plasma concentration of lactate dehydrogenase. After administration, it is rapidly removed from the blood and enters various tissues. Significant levels of UAMC-3203 were detected in the tissues tested, such as liver, kidney and lung.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 10 nM

Target	Value
Ferroptosis (IMR-32 neuroblastoma cells)

References

[1] Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. DOI:10.1021/acs.jmedchem.8b01299