Description
Penicolinate A is a fungal metabolite produced by
Penicillium sp. BCC16054 with diverse biological activities.
1 It exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for
P. falciparum and
M. tuberculosis H37Ra, respectively). Penicolinate A is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC
50s = 7.49, 18.43, 4.4, and 14.08 μM, respectively).
References
1. Intaraudom, C., Boonyuen, N., Suvannakad, R., et al.
Penicolinates A–E from endophytic Penicillium sp. BCC16054 Tetrahedron Lett. 54(8),744-748(2013).
