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Penicolinate A is a fungal metabolite produced by Penicillium sp. BCC16054 with diverse biological activities.¹ It exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for P. falciparum and M. tuberculosis H37Ra, respectively). Penicolinate A is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC₅₀s = 7.49, 18.43, 4.4, and 14.08 μM, respectively).

Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities[1].

1. Intaraudom, C., Boonyuen, N., Suvannakad, R., et al. Penicolinates A–E from endophytic Penicillium sp. BCC16054 Tetrahedron Lett. 54(8),744-748(2013).