Uses
NNC 711 is an anticonvulsant agent and a selective GABA uptake inhibitor (1,2).
Uses
NO-711 hydrochloride is suitable for use as γ-aminobutyric acid (GABA) transporter-1 (GAT-1) antagonists or GABA uptake inhibitor.
Biological Activity
Potent and selective inhibitor of GABA uptake by GAT-1 (IC 50 values are 0.04, 171, 1700 and 622 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo .
Biochem/physiol Actions
NO-711 is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.
storage
Desiccate at +4°C
![1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE Structure](https://www.chemicalbook.com/CAS/GIF/145645-62-1.gif)