Description
The poly(ADP-
ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-
Isoquinolinediol is an inhibitor of poly(ADP-
ribose) synthetase (PARP1; IC
50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-
induced cell death. This compound can be used with cells in culture and in animals.
Chemical Properties
white to off-white solid
Uses
Reagent used in the preparation of PARP inhibitor.
Uses
1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.
Definition
ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.
General Description
A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC
50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.
Biochem/physiol Actions
Cell permeable: yes
