Description
Azido-PEG24-NHS ester is a monodisperse, high purity PEG linker. The azide group enables Click Chemistry. The NHS ester can be used to label the primary amines (-NH2) of proteins, oligonucleotides, and other amine-containing biomolecules. The hydrophilic PEG spacer adds to the water solubility of this reagent.
Uses
Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG24-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Application
Azido-PEG24-NHS ester (CAS 2375600-46-5) is a high-purity PEG derivative widely used in the development of novel drug conjugates and for bio-conjugation reactions; it is also employed as a surface modifier in drug delivery systems and biomedical applications.
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:
10.1016/j.ebiom.2018.09.005
