H2N-PEG9-OH

Description

Amino-PEG9-alcohol is a PEG linker containing amine and hydroxyl moieties. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group can react to allow for further derivatization of the compound.

Uses

Amino-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Sitterley KA, et al. Identification of Proprietary Amino Ethoxylates in Hydraulic Fracturing Wastewater Using Liquid Chromatography/Time-of-Flight Mass Spectrometry with Solid-Phase Extraction. Anal Chem. 2018 Sep 18;90(18):10927-10934. DOI:10.1021/acs.analchem.8b02439