Description
11-keto Testosterone (CRM) (Item No. 9002654) is a certified reference material that is structurally categorized as an androgen. It is a significant hormone in certain fish, regulating the development of sexual development and behavior. 11-keto Testosterone binds the stickleback kidney androgen receptor (EC
50 = 43 nM). 11-keto Testosterone, at 10 nM, significantly activates the human androgen receptor expressed in zebrafish liver cells. This product is intended for research and forensic applications.
Uses
A metabolite of Adrenosterone.
Definition
ChEBI: 11-oxotestosterone is a 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11. It has a role as an androgen, a marine xenobiotic metabolite and a human metabolite. It is a 3-oxo-Delta(4) steroid, an 11-oxo steroid, an androstanoid and a 17beta-hydroxy steroid. It is functionally related to a testosterone. It derives from a hydride of an androstane.
Biochem/physiol Actions
11-Ketotestosterone is a minor androgen in humans, but a major androgen in fish.
in vivo
In previtellogenic cultured sterlet (Acipenser ruthenus), silastic strips embedded with 11-Ketotestosterone (5 or 25 mg/kg) are implanted in vivo for 30 days. Ovarian masculinization or sex reversal is not observed. 11-Ketotestosterone promotes sterlet ovarian development in a dose-dependent manner[1].
References
[1] TAKAFUMI YAMAGUCHI Masahiro S Hironobu Watanuki. Effects of estradiol, progesterone and testosterone on the function of carp, Cyprinus carpio, phagocytes in vitro[J]. Comparative Biochemistry and Physiology C-toxicology & Pharmacology, 2001, 129 1: Pages 49-55. DOI:
10.1016/s1532-0456(01)00176-4[2] GODWIN J. Neuroendocrinology of sexual plasticity in teleost fishes[J]. Frontiers in Neuroendocrinology, 2010, 31 2: Pages 203-216. DOI:
10.1016/j.yfrne.2010.02.002[3] PER-ERIK OLSSON. Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone.[J]. Reproductive Biology and Endocrinology, 2005, 3: 37. DOI:
10.1186/1477-7827-3-37
