N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan

Description

NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC₅₀ = 50 nM for formation of fibrils from Aβ1-42). It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.

Uses

NQTrp is a inhibitor of Aβ1-42 aggregation, altering Aβ self-assembly and reducing toxicity.

References

[1]. scherzer-attali r, pellarin r, convertino m, et al. complete phenotypic recovery of an alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. plos one. 2010 jun 14;5(6):e11101.
[2]. zhang t, xu w, mu y, et al. atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-l-tryptophan inhibitor on alzheimer's aβ1-42 dimer in terms of aggregation and toxicity. acs chem neurosci. 2014 feb 19;5(2):148-59.