N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide

Description

KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 μM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.

Uses

N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.

Uses

N,N''-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.

storage

Store at -20°C

References

[1] NARITA T, YIN S, GELIN C F, et al. Data from Identification of a Novel Small Molecule HIF-1α Translation Inhibitor[C]//49 1. 2023: 0. DOI:10.1158/1078-0432.c.6517576.v1