Uses
BRL 15572 Hydrochloride is an analog of BRL 15572, which is a preferential antagonist at native human 5-HT1D receptors.
Biological Activity
A selective h5-HT 1D antagonist, displaying 60-fold selectivity over h5-HT 1B , and exhibiting little or no affinity for a range of other receptor types.
in vivo
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].
References
[1] price g w, burton m j, collin l j, et al. sb-216641 and brl-15572–compounds to pharmacologically discriminate h5-ht1b and h5-ht1d receptors. naunyn-schmiedeberg's archives of pharmacology, 1997, 356(3): 312-320.
