Description
Isoprostanes are produced by the non-
enzymatic, free radical peroxidation of phospholipid-
esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity.
ent-
8-
iso-
15(S)-
Prostaglandin F
2α (
ent-8-
iso-
15(S)-
PGF
2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC
50 values of 15 and 24 nM, respectively. This isoprostane is about ten-
fold more potent than 8-
iso-
PGF
2α in a whole blood platelet aggregation inhibition assay.
