Description
Carbaprostacyclin is a structural analog of prostacyclin (PGI2) with about 1/10 the receptor binding affinity of prostacyclin.1 Carbaprostacyclin is a relatively indiscriminant ligand for prostaglandin receptors, binding to all the recombinant human PG receptors, except the TP receptor, with an affinity which is a significant fraction of the natural ligand.2 Carbaprostacyclin-biotin is therefore a useful affinity ligand for the binding and purification of a number of different receptors subtypes.WARNING This product is not for human or veterinary use.
References
[1] K SCHRÖR. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374)–equipotent to PGI2 in vitro.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1981, 316 3: 252-255. DOI:
10.1007/bf00505658[2] MARK ABRAMOVITZ . The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2000, 1483 2: Pages 285-293. DOI:
10.1016/s1388-1981(99)00164-x
