Chemical Properties
Colorless to Almost colorless clear liquid.
Uses
Cyclobutanemethanol was used in the synthesis of bicyclic lactone.
Application
Cyclobutanemethanol is a drug used to treat inflammatory diseases. It is an uptake inhibitor that blocks the transport of uridine into cells, preventing the activation of G-protein coupled receptors and the subsequent production of inflammatory mediators. Cyclobutanemethanol has been shown to have anti-inflammatory properties by inhibiting the CB2 receptor, which is found in large quantities in inflammatory tissues. It also prevents dehydration and increases blood flow to inflamed areas by acting on vascular endothelial cells. It has been shown to inhibit influenza virus replication in vitro, but not in vivo.
General Description
Oxidation of cyclobutanemethanol in the presence of lead tetraacetate and lead tetraacetate/metal chloride has been investigated.
Synthesis
Cyclobutanemethanol can be synthesized from two molecules of hydrochloric acid and one molecule of cyclobutane. The synthesis pathway includes removal of a hydroxy group and addition of an alkynyl group via hydrogen bonding interactions with chloride ions.
