Etamsylate

Chemical Properties

White Solid

Uses

Hemostatic;prostaglandin synthesis inhibitor

Uses

Haemostatic / Anti Coagulant

Definition

ChEBI: Etamsylate is a sulfonic acid derivative and an organosulfur compound.

Biological Activity

Etamsylate is a haemostatic agent th at is used for the management of blood loss. Apparently etamsylate increases capillary wall resistance and platelet adhesives by inhibition of the biosynthesis of prostaglandins causing platelet disaggregation in a presence of vascular wound. Recent studies suggest th at etamsylate antagonizes anti-coagulant activity of heparin.

Mechanism of action

Etamsylate is an antihaemorrhagic and vasoprotective agent. It increases platelet adhesiveness and capillary vascular wall resistance, thereby reducing capillary exudation and blood loss.

Clinical Use

Short-term treatment of blood loss in menorrhagia
Prophylaxis of surgical bleeding (unlicensed)

Side effects

Significant: Hypotension (parenteral). Rarely, severe hypersensitivity reaction, including anaphylaxis.
Blood and lymphatic system disorders: Parenteral: Rarely, neutropenia, agranulocytosis, thrombocytopenia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain or discomfort.
General disorders and administration site conditions: Asthenia (parenteral). Rarely, fever.
Musculoskeletal and connective tissue disorders: Rarely, arthralgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Rarely, thromboembolism (parenteral).

Metabolism

Etamsylate is excreted unchanged, mainly in the urine.