Description
8-
iso Prostaglandin F
2β (8-
iso PGF
2β) is an isomer of PGF
2α with a non-
enzymatic, non-
cyclooxygenase origin. It is one of 64 possible isomers of PGF
2α which can be produced by free radical peroxidation of arachidonic acid. 8-
iso PGF
2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-
iso PGF
2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-
iso PGE
1, 8-
iso PGE
2, or 8-
iso PGF
2α