Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- Product NameMaleimido-Tri(Ethylene Glycol)-Propionic Acid
- CAS518044-40-1
- CBNumberCB51562148
- MFC13H19NO7
- MW301.29
- MDL NumberMFCD23103943
- MOL File518044-40-1.mol
- MSDS FileSDS
Chemical Properties
| Boiling point | 491.4±40.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | Liquid |
| pka | 4.28±0.10(Predicted) |
| color | Colorless to light yellow |
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0107746 | 100mg | $34 | Maleimido-tri(ethylene glycol)-propionic acid ≥98% |
Buy |
| ChemScene CS-0107746 | 250mg | $47 | Maleimido-tri(ethylene glycol)-propionic acid ≥98% |
Buy |
| ChemScene CS-0107746 | 1g | $185 | Maleimido-tri(ethylene glycol)-propionic acid ≥98% |
Buy |
| ChemScene CS-0107746 | 5g | $924 | Maleimido-tri(ethylene glycol)-propionic acid ≥98% |
Buy |
| Apolloscientific BIPG1493 | 50mg | $32 | Mal-PEG3-acid 95% |
Buy |
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Chemical Properties,Usage,Production
Description
Mal-PEG3-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.Biological Activity
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It was used in the preparation of neolymphostin-based ADC precursors for the conjugation of site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTAC Linker for the synthesis of PROTACs.in vitro
Mal-PEG3-C2-acid can be used to synthesize linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 195 and 202 nM, respectively. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 286 and 274 nM, respectively.
target
| Cleavable
| PEGs
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 89508211 18501085097 |
sales.bj@hwrkchemical.com | China | 9409 | 55 | |
| +86 (0) 571 85 58 67 18 | China | 18187 | 66 | ||
| 021-60343070 | China | 12731 | 55 | ||
| 400-164-7117 18317119277 |
product02@bidepharm.com | China | 40000 | 60 | |
| 400-8592883 15367835770 |
sales@huatengsci.com | China | 5869 | 58 | |
| 19916721580 | mafarm@126.com | China | 4532 | 58 | |
| 21-65679720 | service@speedchemical.com | China | 604 | 55 | |
| 15618758386 15618758386 |
sales3@myuchem.com | China | 2000 | 55 | |
| 13006575422@163.com | China | 6347 | 58 | ||
| 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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518044-40-1, Maleimido-Tri(Ethylene Glycol)-Propionic AcidRelated Search
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