Synthesis
General procedure for the synthesis of 4-amino-6-chloro-2-methoxypyrimidine from 4-amino-2,6-dichloropyrimidine and sodium methanol: Sodium methanol (12 mL, 25% wt of methanol solution) was added to methanol (300 mL), followed by addition of 4-amino-2,6-dichloropyrimidine (5.00 g, 30.5 mmol) to the mixture. The reaction mixture was heated to reflux for 2 h. After completion of the reaction, the solution was evaporated to dryness. The residue was treated with deionized water (250 mL) and the precipitate formed was separated by filtration and dried under vacuum to afford the title product 4-amino-6-chloro-2-methoxypyrimidine as a white solid (3 g, 61% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.92 (3H, s), 5.21 (2H, br s), 6.14 (1H, s).
