Description
(R)-4-Methoxy dalbergione is the main allergen of
Dalbergia nigra and Dalbergia latifolia Roxb. (East
Indian rosewood, palissandre). Occupational sensitization
occurs in timberworkers.
Uses
(R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens[1][2].
Definition
ChEBI: (R)-4''-methoxydalbergione is a member of the class of 1,4-benzoquinones that is p-benzoquinone substituted by a methoxy group at position 2 and a 1-phenylallyl group at position 5. Isolated from the heartwood of Dalbergia louveli, it exhibits antiplasmodial activity. It has a role as a metabolite and an antiplasmodial drug. It is an enol ether and a member of 1,4-benzoquinones.
References
[1] Khan WN, et al. New natural urease inhibitors from Ranunculus repens. J Enzyme Inhib Med Chem. 2006 Feb;21(1):17-9. DOI:
10.1080/14756360500319210
