ezlopitant
- Product Nameezlopitant
- CAS147116-64-1
- CBNumberCB51343752
- MFC31H38N2O
- MW454.65
- MOL File147116-64-1.mol
- MSDS FileSDS
ezlopitant Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0027059 | 1mg | $149 | Ezlopitant |
Buy |
| ChemScene CS-0027059 | 5mg | $356 | Ezlopitant |
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| ChemScene CS-0027059 | 10mg | $531 | Ezlopitant |
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| aablocks AA00ACJF | 1mg | $88 | (2S,3S)-2-(Diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine |
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| aablocks AA00ACJF | 5mg | $188 | (2S,3S)-2-(Diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine |
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ezlopitant Chemical Properties,Usage,Production
Uses
Treatment of emesis, pain, and inflammation (substance P [NK-1] receptor antagonist).in vivo
Ezlopitant (CJ-11,974; 2, 5, 10 mg/kg; i.p.; 30 minutes) decreases both sucrose and ethanol operant-self administration in rats[1].
Pharmacokinetic Parameters of Ezlopitant in Rat, Gerbil, Guinea pig, Ferret, Dog, Monkey [2].
| Rat (IV; 1 mg/kg) | Gerbil (IV; 1 mg/kg) | Guinea pig (IV; 0.2 mg/kg) | Ferret (SC; 0.8 mg/kg) | Dog (IV; 1 mg/kg) | Monkey (IV; 1 mg/kg) | |
| Tmax (h) | 5.3 | 0.3 | 0.3 | 0.9 | 0.8 | |
| Cmax (ng/mL) | 18 | 5.98 | 106 | 5.98 | 198 | |
| AUC0-∞ (ngh/mL) | 257 | 125 | 35.5 | 528 | 634 | 478 |
| t1/2 (h) | 7.7 | 2.9 | 0.6 | 2.2 | 2.5 | 5.0 |
| CLp (mL/min/kg) | 65 | 136 | 98 | 27 | 27 | 42 |
| F (%) | 15 | 2.1 | 17 | 28 | 2.7 |
| Animal Model: | Male, Long-Evans rats (233±2 g)[1] |
| Dosage: | 2, 5 or 10 mg/kg |
| Administration: | IP; single dose |
| Result: | Attenuated the number of active lever presses for 5% sucrose. Highest dose significantly inhibited operant self-administration of 10% ethanol compared with vehicle. |
Preparation Products And Raw materials
ezlopitant Supplier
Global(13)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 010-56205725 | waley188@sohu.com | China | 12323 | 58 | |
| 16314854226; +8616314854226 |
inquiry@bocsci.com | United States | 19852 | 58 | |
| +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 | |
| 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 5984 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 | |
| 15002134094 | marketing@targetmol.cn | China | 29873 | 58 | |
| 18012923235 18012923235 |
chinasales04@tlcstandards.com.cn | China | 7840 | 58 | |
| 15787879035 15787875101 |
ydw9035@rmastandards.com | China | 9994 | 58 | |
| 13370042665 18916960931 |
2596183085@qq.com | China | 17234 | 58 | |
| 18012923235 | chinasales04@tlcstandards.com.cn | China | 8301 | 58 |
View Latest Prices from ezlopitant manufacturers
ezlopitant Spectrum
147116-64-1, ezlopitantRelated Search
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- Pyrrolidine, 2-[5-(1,1-dimethylethyl)-2-methoxyphenyl]-4-methyl- (9CI)
- Pyrrolidine, 2-(2,4-dimethoxyphenyl)-4-methyl- (9CI)
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