PL017

PL-017 has an IC ₅₀ of 10000 nM for ¹²⁵ I-DADLE binding to δ site.

PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.

IC50: 5.5 nM ( ¹²⁵ I-FK 33,824 binding to μ site)