4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE

Definition

ChEBI: CGH 2466 is a member of thiazoles.

Biological Activity

Adenosine A 1 , A 2B and A 3 receptor antagonist (IC 50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC 50 = 187-400 nM) and phosphodiesterase type 4D (IC 50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo . Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.