Description
SP-8356 an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling.
References
[1] K. PAHK. A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation[J]. Journal of Translational Medicine, 2019. DOI:
10.1186/s12967-019-2024-y[2] KISOO PAHK. SP-8356, a Novel Inhibitor of CD147-Cyclophilin A Interactions, Reduces Plaque Progression and Stabilizes Vulnerable Plaques in apoE-Deficient Mice.[J]. International Journal of Molecular Sciences, 2019, 21 1. DOI:
10.3390/ijms21010095[3] CHUNG JU . Discovery of novel (1S)-(−)-verbenone derivatives with anti-oxidant and anti-ischemic effects[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 19: Pages 5421-5425. DOI:
10.1016/j.bmcl.2013.07.038[4] SUNAM MANDER. SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.[J]. Scientific Reports, 2019: 6595. DOI:
10.1038/s41598-019-41224-y
