Description
Cymoxanil-d
3 is intended for use as an internal standard for the quantification of cymoxanil by GC- or LC-MS. Cymoxanil is a cyanoacetamide fungicide. It inhibits the mycelial growth of 12 isolates of
P. infestans with EC
50 values of 0.27-0.57 μg/ml. Cymoxanil (5-100 mg/L) inhibits the growth of several strains of
S. cerevisiae (IC
50s = 8-25 mg/L) but not
S. pombe,
K. marxianus,
P. anomala, or
C. utilis. A spray application of cymoxanil (1 mg/ml) one day after inoculation of potato leaves with
P. infestans and cucumber leaves with
P. cubensis reduces blighted leaves by 79 and 60%, respectively. It is toxic to rats with an acute LD
50 value of 3.8 mmol/kg. Formulations containing cymoxanil have been used to prevent fungal growth on crops and treat late potato blight in agriculture.
References
[1] Y. COHEN M G. Control of metalaxyl-resistant causal agents of late blight in potato and tomato and downy mildew in cucumber by cymoxanil[J]. Phytopathology, 1987, 77 1: 1283-1288. DOI:
10.1094/phyto-77-1283[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] EMIL REKANOVI. Toxicity of metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb to Phytophthora infestans isolates from Serbia.[J]. Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 2012, 47 5: 403-409. DOI:
10.1080/03601234.2012.657043[4] I.C. RIBEIRO . Yeasts as a model for assessing the toxicity of the fungicides Penconazol, Cymoxanil and Dichlofluanid[J]. Chemosphere, 2000, 41 10: Pages 1637-1642. DOI:
10.1016/s0045-6535(00)00039-4[5] MABROUK HAMADACHE . A Quantitative Structure Activity Relationship for acute oral toxicity of pesticides on rats: Validation, domain of application and prediction[J]. Journal of Hazardous Materials, 2016, 303: Pages 28-40. DOI:
10.1016/j.jhazmat.2015.09.021
