(R)-3-Aminopyrrolidine

Synthesis

114715-38-7

79286-79-6

General procedure for the synthesis of (S)-3-aminopyrrolidine from (S)-1-benzyl-3-aminopyrrolidine: 7.0 g of (S)-1-benzyl-3-aminopyrrolidine, 25 mL of methanol, and 0.7 g of 5% Pd/C catalyst were added to a 100 mL autoclave. The hydrogen pressure was adjusted to 1 MPa, the temperature was raised to 70 °C and the reaction was kept stirring for 8 hours. Upon completion of the reaction, it was cooled to room temperature and the pressure was slowly released. The reaction mixture was filtered to remove the catalyst and the mother liquor was concentrated and purified by distillation to collect the 80-83 °C/40 kPa fraction to give 3.2 g of (S)-3-aminopyrrolidine. The product was analyzed with 99% chemical purity and 90% optical purity e.e.

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