Uses
(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
Biological Activity
(-)-Zuonin A (D-Epigalbacin), a natural lignin, is a potent and selective inhibitor of JNKs with IC50 values of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
in vitro
()-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs.
()-zuonin A
target
| JNK1 1.7 μM (IC 50 ) | JNK2 2.9 μM (IC 50 ) | JNK3 1.74 μM (IC 50 ) |
IC 50
JNK1: 1.7 μM (IC
50); JNK2: 2.9 μM (IC
50); JNK3: 1.74 μM (IC
50)
References
[1] Tamer S. Kaoud, et al. Manipulating JNK Signaling with ()-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883. DOI:
10.1021/cb300261e
