Biological Activity
1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-stearoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS. 1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1β production in isolated human blood monocytes when used at a concentration of 12.5 μM.1 Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.2
References
1.Liu-Wu, Y., Hurt-Camejo, E., and Wiklund, O.Lysophosphatidylcholine induces the production of IL-1β by human monocytesAtherosclerosis137(2)351-357(1998)
2.Dong, J., Xiaoming, C., Zhao, L., et al.Lysophosphatidylcholine profiling of plasma: Discrimination of isomers and discovery of lung cancer biomarkersMetabolomics6(4)478-488(2010)
