Uses
Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].
Biological Activity
Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes (EC 50 =100 nM).
References
[1] Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc.?2004 Feb 18;126(6):1590-1. DOI:
10.1021/ja038950i[2] Mike AK, et al. Small molecule?cardiogenol C?upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem.?2014;33(1):205-21. DOI:
10.1159/000356663
