Uses
Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Biological Activity
Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].
References
[1] EDWARD M RUSSAK Edward M B. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals.[J]. Annals of Pharmacotherapy, 2019, 53 2: 211-216. DOI:
10.1177/1060028018797110.
[2] W. GREENAWAY F. R W. A convenient synthesis of creatine-15N from glycine-15N via sarcosine-15N[J]. Journal of labelled compounds & radiopharmaceuticals, 1978, 14 4: 611-615. DOI:
10.1002/jlcr.2580140417.
[3] HE J, ZHANG X, HE Q, et al. Synthesis of 15N-labeled heterocycles via the cleavage of C–N bonds of anilines and glycine-15N†[J]. Chemical Communications, 2021, 44: 5442-5445. DOI:
10.1039/D1CC01734A.
[4] T P STEIN. Measurement of protein synthesis rates with [15N]glycine.[J]. American Journal of Physiology, 1980, 239 4: E294-E300. DOI:
10.1152/ajpendo.1980.239.4.E294.
[5] MOSTAFA OTHMAN. Millimeter-Sized Clusters of Triple Cation Perovskite Enables Highly Efficient and Reproducible Roll-to-Roll Fabricated Inverted Perovskite Solar Cells[J]. Advanced Functional Materials, 2021, 32 12. DOI:
10.1002/adfm.202110700.
