Ac-WEAD-AMC (trifluoroacetate salt) Chemical Properties,Usage,Production
Description
Ac-WEAD-AMC is a fluorogenic substrate for caspase-1 and caspase-4.1 Upon enzymatic cleavage by caspase-1 or caspase-4, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 or caspase-4 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.WARNING This product is not for human or veterinary use.
References
[1] DENNIS LEE ∗ . A substrate combinatorial array for caspases[J]. Bioorganic & Medicinal Chemistry Letters, 1999, 9 12: Pages 1667-1672. DOI: 10.1016/s0960-894x(99)00260-7
