Ac-WEAD-pNA (trifluoroacetate salt) Chemical Properties,Usage,Production
Description
Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4.1 Caspase-1 and caspase-4 preferentially bind to and cleave the Trp-Glu-Ala-Asp (WEAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.WARNING This product is not for human or veterinary use.
References
[1] DENNIS LEE ∗ . A substrate combinatorial array for caspases[J]. Bioorganic & Medicinal Chemistry Letters, 1999, 9 12: Pages 1667-1672. DOI: 10.1016/s0960-894x(99)00260-7
