Uses
omega-Agatoxin TK is a selective blocker of the P-type Ca2+?channel.
Uses
ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.
General Description
CACNA1A (calcium voltage-gated channel subunit alpha1 A)?gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.
Biochem/physiol Actions
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
storage
-20°C (desiccate)
