DENDROTOXIN I

Uses

Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research[1][2][3].

in vivo

IC 50

Kv1.1: 0.13-50 nM (IC₅₀); Kv1.2: 0.13-50 nM (IC₅₀); Kv1.6: 0.13-50 nM (IC₅₀)

References

[1] Qiwen Liao, et al. Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing. J Proteome Res. 2018 Feb 2;17(2):891-902. DOI:10.1021/acs.jproteome.7b00686
[2] Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584. DOI:10.1038/srep28584
[3] Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103(7):2177-2183. DOI:10.1002/jps.24019