Chemical Properties
CLEAR LIGHT YELLOW TO ORANGE-RED LIQUID
Uses
2,4,4,6-TetraMethyl-1-oxa-3-aza-2-cyclohexene is used for α-carbanion serves as acetate or acetaldehyde enolate equivalent for synthesis of α,β-unsaturated aldehydes, aliphatic aldehydes, α-amino ketones, unsymmetrical ketones, and substituted carboxylic acids.
Synthesis Reference(s)
The Journal of Organic Chemistry, 22, p. 839, 1957
DOI: 10.1021/jo01358a612
Synthesis
2,4,4,6-TetraMethyl-1-oxa-3-aza-2-cyclohexene is synthesized by the acid-catalyzed condensation of Acetonitrile and 2-methyl-2,4-pentanediol in 65% yield (eq 1).
storage
2,4,4,6-TetraMethyl-1-oxa-3-aza-2-cyclohexene can be stored for months at rt under an inert atmosphere.
