Chemical Properties
light green to grey powder
Uses
Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Uses
antibacterial, antifungal
Definition
ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 70, p. 8590, 2005
DOI: 10.1021/jo051191x
in vitro
Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
in vivo
Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
